PRMT5 methylates TP53 [GO_0035243]
Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N’(omega)-dimethyled arginine residues. Note that type II protein arginine N-methyltransferase enzymes possess ‘protein-arginine omega-N monomethyltransferase activity ; GO:0035241’ and ‘protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243’.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen PRMT5 methylates TP53 in VFB
VFB Term Json
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"Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues."
],
"comment": [
"Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'."
]
},
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"version": "44725ae",
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"label": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)"
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