SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites [GO_0008568]
Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. See also the cellular component term ‘katanin complex ; GO:0008352’.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites in VFB
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0008568",
"symbol": "",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0008568",
"label": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites"
},
"description": [
"Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP."
],
"comment": [
"See also the cellular component term 'katanin complex ; GO:0008352'."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0140096",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0140096",
"label": "catalytic activity, acting on a protein"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0140776",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0140776",
"label": "protein-containing complex destabilizing activity"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0140657",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0140657",
"label": "ATP-dependent activity"
}
],
"relationships": [
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/BFO_0000050",
"label": "is part of",
"type": "part_of"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0000226",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0000226",
"label": "microtubule cytoskeleton organization"
}
}
],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
"scope": "has_exact_synonym",
"label": "ATP phosphohydrolase (tubulin-dimerizing)",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "microtubule-severing ATPase activity",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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"pub"
],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
},
{
"synonym": {
"scope": "has_narrow_synonym",
"label": "katanin activity",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
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"pub"
],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": []
}
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