transcription corepressor activity [GO_0003714]
A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen transcription corepressor activity in VFB
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/GO_0003714",
"symbol": "",
"types": [
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],
"short_form": "GO_0003714",
"label": "transcription corepressor activity"
},
"description": [
"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators."
],
"comment": [
"For usage guidance, see comment in GO:0003712 ; transcription coregulator activity."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0003712",
"types": [
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"label": "transcription coregulator activity"
}
],
"relationships": [
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"relation": {
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"label": "is part of",
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"object": {
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"iri": "http://purl.obolibrary.org/obo/GO_0045892",
"types": [
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"short_form": "GO_0045892",
"label": "negative regulation of DNA-templated transcription"
}
}
],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
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"type": ""
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"FlyBase": "",
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},
{
"synonym": {
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"label": "RNA polymerase II transcription corepressor activity",
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},
{
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}
],
"def_pubs": []
}
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